The Structure of the NPC1L1 N-Terminal Domain in a Closed Conformation
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چکیده
منابع مشابه
The Structure of the NPC1L1 N-Terminal Domain in a Closed Conformation
BACKGROUND NPC1L1 is the molecular target of the cholesterol lowering drug Ezetimibe and mediates the intestinal absorption of cholesterol. Inhibition or deletion of NPC1L1 reduces intestinal cholesterol absorption, resulting in reduction of plasma cholesterol levels. PRINCIPAL FINDINGS Here we present the 2.8 Å crystal structure of the N-terminal domain (NTD) of NPC1L1 in the absence of chol...
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ژورنال
عنوان ژورنال: PLoS ONE
سال: 2011
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0018722